If you ask me what caused this exception,i am really not sure about that but would like to share what helped me to resolve this  Microsoft JScript runtime error: Sys.WebForms.PageRequestManagerServerErrorException: An unknown error occurred while processing the request on the server. The status code returned from the server was: 500

To resolve this, set the validateRequest attribute of the Page directive to false ValidateRequest=”false”

Read more about this attribute here http://www.asp.net/learn/whitepapers/request-validation


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